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伦敦数名医学博士接二连三的诡异惨死引起了警方的重视。经过调查Trout督查发现这几名死者的致死手法都出自于埃及十灾的典故，而他们的唯一共同点是都曾和Vesalius博士在一次失败的手术中共事过。而手术中意外死去病人的丈夫Anton Phibes博士成为了最大的嫌犯，但Vesalius博士却告诉Trout督查Anton Phibes博士却早已在车祸中丧生……。Based on the Stephen Potter "One Upmanship" and "Lifemanship" books, Henry Palfrey tries hard to impress but always loses out to the rotter Delauney. Then he discovers the Lifeman college run by "Professor" Potter and discovers the secrets of success. But has he the courage to put all his lessons into effect ?。